Mitigating prolonged QT interval in cancer nanodrug development for accelerated clinical translation
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چکیده
منابع مشابه
Mitigating prolonged QT interval in cancer nanodrug development for accelerated clinical translation
BACKGROUND Cardiac toxicity is the foremost reason for drug discontinuation from development to clinical evaluation and post market surveillance [Fung 35:293-317, 2001; Piccini 158:317-326 2009]. The Food and Drug Administration (FDA) has rejected many potential pharmaceutical agents due to QT prolongation effects. Since drug development and FDA approval takes an enormous amount of time, money ...
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Prolonged heart-rate adjusted QT intervals on the electrocardiogram (ECG) are associated with an increased risk for coronary heart disease and sudden death. However, the diagnosis of the prolonged QT interval is hampered by lack of standards. We studied variations in the prevalence of prolonged QT, based on different common definitions, in a large nonhospitalized population, and compared our re...
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ژورنال
عنوان ژورنال: Journal of Nanobiotechnology
سال: 2013
ISSN: 1477-3155
DOI: 10.1186/1477-3155-11-40